Noopept is the brand name of a smart prescription drug developed and patented in Russia during the 1970’s. It was manufactured by JSC LEKKO Pharmaceuticals since then and is currently available as a prescribed medication in Russia and its neighboring nations. With the increased interest of the population regarding cognitive enhancing compounds, noopept reached USA in 1995 for patent application. However, it is not yet approved by the Food and Drug Administration in US as well as the European Medicines Agency for human use.
Contrary to common belief, noopept does not belong to the racetam family. However, many consider it as a nootropic medicine because it is derived from racetams and it shares comparable modes of action like other nootropic agents. Many experts agree that it is 1000 times more powerful than the first nootropic drug, piracetam .
Noopept is a water soluble, synthetic racetam with a similar chemical structure to piracetam and the amino acids glycine and proline (in cyclical configuration). It is an ethyl ester of N-phenyl-acetyl-L-prolylglycine and a peptide analog of piracetam. It possesses conspicuous neuroprotective and nootropic effects. Additionally, it helps in increasing cycloprolylglycine concentrations, hence, considered as a cycloprolylglycine “prodrug.”
[msgbox]Chemical/IUPAC name: N-phenyl-acetyl-L-prolylglycine ethyl ester
Chemical formula: C17H22N2O4
Chemical properties: Colorless/White crystalline powder
Uses: Cognitive enhancer[/msgbox]
Mechanism of action
Cognitive enhancing mechanism
The modes of action of nope put appears to be similar to other nootropic agents. According to experiments, noopept facilitates the secretion of neurotransmitters found in the brain – one of which is acetylcholine. Acetylcholine communicates synaptic signals between the neurons, thereby resulting to improvement in synapse plasticity. As such, the brain is able to create connections whilst enhance problem solving skills and reasoning abilities.
Noopept is rapidly gaining popularity amongst users and researchers alike because of its novel properties, particularly its neuroprotective mechanisms. These neuroprotective properties appear to originate from its antioxidant and anti-inflammatory qualities. It seems that noopept has the ability to prevent cell death and inhibit free radicals from causing oxidative stress – thus, preventing cell damage on the brain .
Moreover, noopept helps in stimulating the production of brain derived neurotrophic factor as well as nerve growth factor. These brain elements are proteins that play a major role in neuroplasticity. Both these proteins are indispensable influences needed by neurons. Increased production of brain derived neurotrophic factor and nerve growth factor leads to better brain health.
Improved communication mechanism
One unique attribute of noopept is its efficacy in improving communication. Experts believe that this cognitive enhancer enhances the connection of the right and left brain hemispheres. This mechanism improves verbal communication as well as confidence on public/social settings. Additionally, noopept is said to help in alleviating mental workload.
Noopept has many benefits. Its ability to repair damaged brain cells and improve overall cognition excited the entire pharmacological industry, hence, numerous animal and human trials were undertaken to discover its novel effects.
Earlier data revealed that noopept can treat mild cognitive problems on individuals with encephalopathy. Thus, a prospective study involving stroke patients was done to prove this. A total of 60 stroke patient were enlisted as participants and subsequently treated with noopept and placebo for the duration of 12 months. Their cognitive functions were assessed before and after the study period.
Analysis of assessment results showed that there is a significant cognitive function improvement amongst stroke patients who were treated with noopept as compared to the placebo group. Additionally, this study demonstrated that noopept is safe for human use as there were no recorded severe adverse effects .
Another study comparing the efficacy of noopept and piracetam arrived to a comparable conclusion as above. In this particular randomized comparative trial, 53 individuals diagnosed with post traumatic and vascular central nervous system disorders were treated with noopept and piracetam for 56 days. Subjects were assessed before and after the study period using a number of tests. After data analysis, it was revealed that noopept won over piracetam in terms of safety and efficacy .
Alleviation of tuberculosis chemotherapy side effects
In a Russian study, the clinical efficiency of noopept in inhibiting the adverse effects of anti-tuberculous drugs was measured. 60 patients who were recently diagnosed with respiratory tuberculosis were enlisted as participants. They were randomly treated with noopept and a placebo drug. Assessment of the efficacy of noopept treatment revealed that it decreased anxiety symptoms and normalized the antioxidative and nervous systems. Additionally, it reduced the frequency of cardio toxic and neurotoxic responses of the body towards tuberculosis chemo therapeutic drugs .
Most of the studies conducted on noopept were done using animals. One of these studies showed that it can help in treating Alzheimer’s disease through inhibiting its pathogenetic mechanisms involved during neurodegenerative processes . Other studies also showed that noopept has anti-inflammatory, antioxidant, neurotoxicity inhibition and blood rheology improvement effects .
Although there are numerous literature data regarding the efficacy of noopept, precaution upon use is important as it requires more trials to establish its effects on humans.
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