Nootropics Review: Gerovital (GH-3)

Gerovital is a nootropic made by Dr. Ana Aslan in Romania in the 1940s. Around that time, Aslan had been administering a procaine – an anesthetic to patients suffering from arthritis so they can achieve joint pain relief. The majority of her patients ended up with enhanced memory, decreased depression, improved skin tone, more energy, hair color restoration, and overall well-being. These significant results allowed her to conduct further studies to test out effects of procaine to individuals [1].

Gerovital (GH-3) Aslan found that by incorporation benzoic acid as a preservative and potassium metabisulfite as an anti-Oxidant, the molecule of procaine became balanced, and the procaine effects were even more dramatic. She named her enhanced procaine version as “Gerovital” [2].

Gerovital is one of the many widely known rejuvenation products in the globe today. The nootropic is said to provide a potent long-acting anti-depressant properties. Aslan’s test findings have been met with heavy skepticism, and further research outside Aslan’s lab received yielded mixed results [1] [2].

Inhibition of MAO

Gerovital has been proven to hinder MAO (monoamine oxidase); an enzyme found within the brain. MAO is primarily responsible for breaking down the neurotransmitter such as that of serotonin, norepinephrine, and dopamine. As individuals become older, the activity of MAO increases, causing a breakdown of these neurotransmitters. Dopamine, norepinephrine, and serotonin are responsible for feeling of calmness and pleasure. Individuals are taking in the nootropic report of enhanced energy levels, awareness, and mood. Such effects may be due to the inhibition of the MAO [2] [3].

Research Studies

A single study indicated that procaine enhanced the use of oxygen within the brains of older rodents to levels equivalent to that of younger rats. This suggests that this could be another approach that Gerovital can achieve its effects [4].

Gerovital has been given approval by the Romanian government for treating the body’s aging effects. These could include neuralgia, atherosclerosis, neuritis, arthritis, and others [5].

Recent clinical studies reported Gerovitals effects in a varying medical conditions, which include mental retardation, Alzheimer’s, and Parkinson’s disease. Multiple studies conducted compared the effectiveness of the nootropic to Piracetam, leading to similar improvements within the central nervous system processes. Another study led to further improvements in cognitive function when Piracetam was mixed with another drug, Aslavital [1] [6].

There have been other studies that failed to carry out similar findings of the nootropic. The majority of these studies was claiming Gerovital to be false utilized Procaine instead of the actual Gerovital preparation. Researchers believe that Procaine has similar properties to Gerovital. But developers of the nootropic claim the ingredient traces are essential [7].

Side Effects:

There have been no reports of significant negative effects of Gerovital except for very rare allergic reactions [1].

Drug Dosage

A Gerovital tablet can be taken once a day for 25 days. No tablets are ingested for a period of five days prior to the start of another round. Via injectable, the nootropic can be administered once every third day of the month then resting for one prior to the next round. Such complex plan intake was made by Aslan to let the enzymes restore the Procaine breakdown, while desensitizing the Procaine effects. The schedule may be present a challenge for patients to follow. One or two weekly injections on a consistent basis offer an equivalent effect [8].

Purchase

In the United States, Gerovital can only be bought in Nevada. It’s typically available over-the-counter in Romania, in the majority of European countries, and in Mexico [7].

References:

  1. http://www.smart-publications.com/books/full-text/smart-drugs-and-nutrients/smart-drugs-and-nutrients-sec-5/smart-drugs-and-nutrients-sec5-gerovital-gh-3
  2. http://www.ageless.co.za/procaine.htm
  3. http://www.emaxhealth.com/1275/banned-antiaging-drug-gerovital-h3-makes-comeback
  4. http://books.google.com.pk/books?id=UKgfDsRffnkC&pg=PA371&lpg=PA371&dq=procaine+enhanced+the+use+of+oxygen&source=bl&ots=GYC5Jor3wD&sig=UANj8dR0ckFYrFPdY6xJItyGLtk&hl=en&sa=X&ei=08FTVIu8BdbsaPGcgfAH&ved=0CB0Q6AEwAA#v=onepage&q=procaine%20enhanced%20the%20use%20of%20oxygen&f=false
  5. http://intelegen.com/nutrients/dmae_and_paba_an_alternative_to.htm
  6. http://www.zalmo.com/scientificstudies.pdf
  7. http://en.wikipedia.org/wiki/Gerovital
  8. http://www.drugs.com/npp/kh-3.html
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