Nootropic Review: Selank

Selank is an anxiolytic heptapeptide and a nootropic made by the Institute of Molecular Genetics of the Russian Academy of Sciences. It has been widely considered as a nootropic with anxiolytic effects. Selank is a synthetically analog of the peptide Tuftsin. It’s known for enhancing and altering the immune system in a positive manner. This have led the nootropic to be classified under the immunomodulatory category.

Selank

Semax, along with another heptapeptide nootropic, was made by researchers at the Molecular Genetics of the Russian Academy of Sciences. The substance is very much related to Selank and has been approved for use in humans in Russia and Ukraine. A number of reports from users and researchers showed that Selank is far more efficient choice than Semax. The nootropic, however, recently wrapped up the third stage of clinical trials in Russia. It’s now waiting a green light for public use [1] [2].

Dosages

Selank dosageIn general, a 250 to 500 mg of the drug should be taken at once or twice daily. Selank isn’t bio-available orally since it’s a peptide that is hydrolyzed and broken down into amino acids within the gut. As a result, both methods of intake are either through subcutaneous injection or intranasal. If you happen to have purchased freeze-dried Selank powder, it should remain stable for three months although it’s recommended to store it in the fridge as much as possible.

Meanwhile, a lyophilized Selank will entail a reconstitution with bacteriostatic water prior to intranasal or subcutaneous injection [3].

Mechanism

From a pharmacological point of view, the nootropic mimics a majority of its results from Tuftsin – that is a peptide where it’s sourced upon. Such effects involve balancing T-helper cells and a modulation expression of the Interleukin-6.

Furthermore, there’s increasing evidence suggesting Selank may be able to modulate the expression of the neurotropic factor.

Selank’s action processes are believed to be related to serotonin increase. Serotonin is primarily responsible for influencing a person’s appetite, positive mood, and regulation of the wake and sleep cycle. It’s also proven that a state lacking serotonin can lead to painful sleep, depression, and lack of hunger.

A study done on mice showed the Selank effects on monomines and their metabolites. It showcased a significant difference in dopamine, norepinephrine, and serotonin content as well as levels in the frontal cortex, hippocampus, and hypothalamus. Additional research supports Selank’s serotonin-increasing capability.

Selank and Tuftsin were also indicated to provide serotonin levels even though rodents were pre-tested with a serotonin synthesis inhibitor, p-chlorophenylalanine. Metabolism of serotonin was improved within half an hour of nootropic administration while Tuftsin remained incapable of raising 5-HIT levels.

Rodents who were exposed to 6-hydroxydopamine, a neurotoxin that destroys the catecholaminergic system, had their cognition processes restored via Selank [4] [5].

Benefits

A mice study that were purposely bred to suffer depression showed the nootropic’s capability in fighting anhedonia and bring back pleasure-seeking behavior. Selank administration led to an increase in sucrose content and less immobility during a forced swim test.

A study that involved 62 patients with a General Anxiety Disorder (GAD) wanted to compare the nootropic to benzodiazepine. 30 patients were given a Selank treatment while the remaining 32 had benzodiazepines. Surprisingly, the effectiveness of both drugs were strikingly similar, but scientists found that the nootropic possessed anti-fatigue effects. Complete study details were hard to extract since it was experimented in Russia, and a sole abstract only indexed by PubMed.

Another study experimented with the immunomodulatory effects of the nootropic given by the fact that its peptide relative Tuftsin has an immune function capability. Selank was given to patients suffering from GAD for two weeks, after which, it was observed Selank have the suppressed depression in patients while leaving healthy participants unaffected. T-helper cells have been modulated with patients who have GAD [6].

Cognitive Enhancing Properties

A study performed on an animal compared Selank to a saline placebo during a food-reward test that featured memory and learning. While certain study details remain unclear, since the test was done in Russia, scientists concluded that the nootropic enhanced memory consolidation. This mainly occurred via an increase in serotonin.

A study conducted in adult rats showcased Selank to compensate hypoxia-induced cognitive deficit while lowering noradrenaline and serotonin levels [6] [7].

 References:

  1. http://en.wikipedia.org/wiki/Selank
  2. http://nootropicsupplementreview.com/selank
  3. http://www.ironmagazine.com/2012/nootropics-selank-peptide-explained
  4. http://www.ncbi.nlm.nih.gov/pubmed/11550013
  5. http://www.ncbi.nlm.nih.gov/pubmed/18454096
  6. http://www.smarternootropics.com/selank
  7. http://www.europsy-journal.com/article/S0924-9338%2812%2975281-1/abstract
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