Nootropic Review: Bacopa


BacopaBacopa is a herb (also considered as a nootropic) that is dominant in Ayurvedic medicine [1]. It’s been recommended traditionally for enhancing memory and treating asthma and epilepsy. The nootropic is also classed as an adaptogen since it’s very effective in mitigating stress [2]. Bacoside, a class of compounds, are believed to be responsible for the majority of the nootropic’s effects, with Bacoside A being frequently studied [3].

Bacopa, as a nootropic, has been the referee frequently an anxiolytic, memory, and cognitive enhance. Based on a plenty of research done with the substance, Bacopa is capable of: [4]

  • Curbing drug-induced amnesia in animals
  • Normalizing levels of neurotransmitters in varying animals
  • Enhancing antioxidant content in the brains of rats
  • Improving memory for humans regardless of age
  • Minimizing anxiety
  • Enhancing workload capacity for individuals suffering from anxiety
  • Limiting error rates in varying cognitive tasks

Nootropic Stack

Bacopa is a recommended addition to the majority of nootropic stacks today. It functions to minimize anxiety and enhance memory. It seems to do so via adaptogenic means and by facilitating normal neurotransmitter levels while limiting dopamine and serotonin spikes after administering morphine in rats.

As a result of its unique processes, it can be stacked with most nootropics (adaptogens excluded), without worrying about overcooking a precise pathway. The supplement seems to take weeks to have an effect and shouldn’t be dependent on as an acute anxiolytic [5].

Dosages of Bacopa

Bacopa is mainly fat soluble and should be ingested with a meal. Each dosage of 150 mg, twice daily is a good starting point. Human clinical trials who have benefited from the drug utilized 150 mg of dosage [6].

Benefits of Bacopa

The nootropic is known to be a memory enhancer in Ayurvedic medicine. Research continues to back this traditional belief today. A rat study done indicated how Bacopa was capable of treating scopolamine-induced amnesia while offering protection against spatial memory impairment [7].

A number of human studies have confirmed that the supplement is capable of enhancing memory to individuals over 50 years of age, improving recall and memory retention and fighting depression.Whatever even more interesting is that a 12-week study done on 46 participants (between the ages of 18to 60 years), confirmed that the nootropic enhances verbal learning, early information processing speed,and memory formation [8] [9].

A study involving 40 children between the ages of six to eight years indicate how Bacopa is capable of:

  • Decreasing the time of reaction, performance, and errors in a visual-motor performance experiment
  • Dramatically enhancing digit span
  • Enhancing reaction time in a Raven’s definite matrices

Another study involving 35 participants with anxiety proved how the nootropic is capable of minimizing the average anxiety score, enhance behavior such as that of interaction, improve memory, and minimize mental fatigue. Such study was done without a placebo. The 35 participants were divided into 2 or 4-week treatment schedules. Both groups saw remarkable improvement, which suggests that Bacopa doesn’t require a lot of time to take effect. However, the biggest benefits were observed in the group who were treated for four weeks [8].

Mechanism of Bacopa

A number of studies indicate that the nootropic is capable of supporting antioxidant brain levels which include catalase, superoxide dismutase, and glutathione. In the brains of rats, Bacopa was shown to offer protection against aluminum and mercury neurotoxicity by minimizing oxidative stress [10].

Safety and Side Effects

Frequent observations in human trials done with Bacopa involved certain forms of gastrointestinal distress, cramping, increased stool frequency, and nausea. It’s sensible to ingest the nootropic with a fatty source (as frequently recommended) to ensure full absorption. Dividing the daily dosages to 2-3 servings may also aid in offsetting Gastrointestinal problems [11].

The recommended dosage of 250 mg per kg found it capable of minimizing spermatogenesis without affecting hormone and libido levels. Such effect can be overturned after termination of intake [12].